Journal article
Low levels of muscarinic M1 receptor–positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia
E Scarr, S Hopper, V Vos, M Suk Seo, IP Everall, TD Aumann, G Chana, B Dean
Journal of Psychiatry and Neuroscience | Published : 2018
DOI: 10.1503/jpn.170202
Abstract
Background: Results of neuroimaging and postmortem studies suggest that people with schizophrenia may have lower levels of muscarinic M1 receptors (CHRM1) in the cortex, but not in the hippocampus or thalamus. Here, we use a novel immunohistochemical approach to better understand the likely cause of these low receptor levels. Methods: We determined the distribution and number of CHRM1-positive (CHRM1+) neurons in the cortex, medial dorsal nucleus of the thalamus and regions of the hippocampus from controls (n = 12, 12 and 5, respectively) and people with schizophrenia (n = 24, 24 and 13, respectively). Results: Compared with controls, levels of CHRM1+ neurons in people with schizophrenia wer..
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Awarded by Australian Research Council
Funding Acknowledgements
The authors thank the staff of the Victorian Brain Bank Network and the Advanced Microscopy Facility, the Florey, for their support. Tissues were received from the Victorian Brain Bank Network, supported by the Florey, the Alfred Hospital and the Victorian Institute for Forensic Medicine. This work was supported by the National Medical and Health Research Council (grants APP1048544, APP1045619, APP1002240 and APP1037234), the Australian Research Council (grants DP110100086 and FT100100689), the Andrew and Claire Henna Ride for Ben, One in Five and the Operation Infrastructure Support Grant from the Victorian State Government.